a functional monomeric GHS - R 1 a receptor reconstituted in lipid discs
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چکیده
Background: Constitutive activity is central to G protein-coupled receptor signaling still the mechanisms underlying it are unknown. Results: the ghrelin receptor monomer reconstituted in a lipid disc activates Gq without agonist and recruits arrestin in a liganddependent manner. Conclusion: high constitutive activity is an intrinsic property of the ghrelin receptor. Significance: this is the first demonstration that the ghrelin receptor has all the determinants for constitutive activity and ligand-regulated internalization.
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تاریخ انتشار 2011